Non-Newtonian Hemodynamics and Shear Stress Distribution in Three Dimensional Model of Healthy and Stented Coronary Artery Bifurcation

نویسندگان

  • Marjan Molavi Zarandi
  • Rosaire Mongrain
  • Olivier F. Bertrand
چکیده

Stent implantation changes the arterial blood flow patterns and consequently changes the magnitude and distribution of Wall Shear Stress (WSS). Knowledge of local blood flow hemodynamics and shear forces are important for understanding the performance of stents. In certain regimes within the stented region (low shear rate regimes) blood should be treated as a non-Newtonian fluid. In this paper, a threedimensional model of the coronary artery bifurcation is developed and blood flow hemodynamics and WSS distribution in both healthy and stented coronary artery bifurcation are analyzed using COMSOL Multiphysics. Our simulation shows that the presence of stent within the bifurcation induces local disturbance in the flow field and consequently produces regions of low and non-uniform shear stress in the main and daughter vessel.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Statistical analysis of the association between rheological properties of blood and atherosclerosis

The aim of this study is to investigate the effects of non-Newtonian blood rheology models on the wall shear stress (WSS) distribution in a cohort of patients-specific coronary arteries. Twenty patients with diseased left anterior descending (LAD) coronary arteries (with varying degrees of stenosis severity from mild to severe) who underwent angiography and in-vivo pressure measurements were se...

متن کامل

Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses.

Non-Newtonian fluid flow in a stenosed coronary bypass is investigated numerically using the Carreau-Yasuda model for the shear thinning behavior of the blood. End-to-side coronary bypass anastomosis is considered in a simplified model geometry where the host coronary artery has a 75% severity stenosis. Different locations of the bypass graft to the stenosis and different flow rates in the graf...

متن کامل

Association of endothelial shear stress with plaque thickness in a real three-dimensional left main coronary artery bifurcation model.

We report for the first time a real three-dimensional reconstruction of the left main coronary artery, left main bifurcation, left anterior descending coronary artery and left circumflex coronary artery using biplane angiography and intravascular ultrasound imaging in a patient with a proximal stenosis in the left anterior descending coronary artery. By using computational fluid dynamics in the...

متن کامل

Numerical investigation of blood flow in a deformable coronary bifurcation and non-planar branch

INTRODUCTION Among cardiovascular diseases, arterials stenosis is recognized more commonly than the others. Hemodynamic characteristics of blood play a key role in the incidence of stenosis. This paper numerically investigates the pulsatile blood flow in a coronary bifurcation with a non-planar branch. To create a more realistic analysis, the wall is assumed to be compliant. Furthermore, the fl...

متن کامل

Computational Fluid Dynamics Analysis of the Effect of Plaques in the Left Coronary Artery

This study was to investigate the hemodynamic effect of simulated plaques in left coronary artery models, which were generated from a sample patient's data. Plaques were simulated and placed at the left main stem and the left anterior descending (LAD) to produce at least 60% coronary stenosis. Computational fluid dynamics analysis was performed to simulate realistic physiological conditions tha...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010